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PNavarro LAB

Publications

Publications

Publications
EBioMedicine

Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis

Martínez-Bosch N, Cristóbal H, Iglesias M, Gironella M, Barranco L, Visa L, Calafato D, Jiménez-Parrado S, Earl J, Carrato A, Manero-Rupérez N, Moreno M, Morales A, Guerra C, Navarro P, García de Frutos P

  • Published
    2022

  • Impact Factor
    11.205

Proceedings of the National Academy of Sciences

Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor-stroma crosstalk

Orozco CA, Martinez-Bosch N, Guerrero PE, Vinaixa J, Dalotto-Moreno T, Iglesias M, Moreno M, Djurec M, Poirier F, Gabius HJ, Fernandez-Zapico ME, Hwang RF, Guerra C, Rabinovich GA, Navarro P

  • Published
    2018

  • Impact Factor
    9.553

Oncotarget

Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker

Martinez-Bosch N, Barranco LE, Orozco CA, Moreno M, Visa L, Iglesias M, Oldfield L, Neoptolemos JP, Greenhalf W, Earl J, Carrato A, Costello E, Navarro P

  • Published
    2018

Cancer Research

Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation

Martínez-Bosch N, Fernández-Barrena MG, Moreno M, Ortiz-Zapater E, Munné-Collado J, Iglesias M, André S, Gabius HJ, Hwang RF, Poirier F, Navas C, Guerra C, Fernández-Zapico ME, Navarro P

  • Published
    2014

  • Impact Factor
    9.280

Journal of Pathology

Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer

Martínez-Bosch N, Iglesias M, Munné-Collado J, Martínez-Cáceres C, Moreno M, Guerra C, Yélamos J, Navarro P

  • Published
    2014

  • Impact Factor
    7.585

Glia

Tpa induces microglial inflammation via a noncatalytic molecular mechanism involving activation of MAPK and Akt signaling pathways and AnxA2 and Gal-1 receptors.

Pineda D, Ampurdanés C, Medina MG, Serratosa J, Tusell JM, Saura J, Planas AM, Navarro P

  • Published
    2012

  • Impact Factor
    5.186

Oncotarget

The pancreatic niche inhibits the effectiveness of sunitinib treatment of pancreatic cancer

Martínez-Bosch N, Guerrero PE, Moreno M, José A, Iglesias M, Munné-Collado J, Anta H, Gibert J, Orozco CA, Vinaixa J, Fillat C, Viñals F, Navarro P

  • Published
    2016

  • Impact Factor
    6.359

Nature Medicine

Key contribution of CPEB4-mediated translational control to cancer progression

Ortiz-Zapater E, Pineda P, Martínez-Bosch N, Fernández-Miranda G, Iglesias M, Alameda F, Moreno M, Eliscovich C, Eyras E, Real FX, Méndez R, Navarro P

  • Published
    2011

  • Impact Factor
    22.864

Gastroenterology

Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer

Roda O, Ortiz-Zapater E, Martínez-Bosch N, Gutiérrez-Gallego R, Vila-Perelló M, Ampurdanés C, Gabius HJ, André S, Andreu D, Real FX, Navarro P

  • Published
    2009

  • Impact Factor
    12.899

The American Journal of Pathology

Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2

Ortiz-Zapater E, Peiró S, Roda O, Corominas JM, Aguilar S, Ampurdanés C, Real FX, Navarro P

  • Published
    2007

  • Impact Factor
    5.487

Proteomics

A proteomic approach to the identification of new tPA receptors in pancreatic cancer cells

Roda O, Chiva C, Espuña G, Gabius HJ, Real FX, Navarro P, Andreu D

  • Published
    2006

  • Impact Factor
    5.735

The EMBO journal

Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation

Medina MG, Ledesma MD, Domínguez JE, Medina M, Zafra D, Alameda F, Dotti CG, Navarro P

  • Published
    2005

  • Impact Factor
    10.053

The American Journal of Pathology

Tissue plasminogen activator in murine exocrine pancreas cancer: selective expression in ductal tumors and contribution to cancer progression

Aguilar S, Corominas JM, Malats N, Pereira JA, Dufresne M, Real FX, Navarro P

  • Published
    2004

  • Impact Factor
    6.441

The Journal of Biological Chemistry

New insights into the tPA-annexin A2 interaction. Is annexin A2 CYS8 the sole requirement for this association?

Roda O, Valero ML, Peiró S, Andreu D, Real FX, Navarro P

  • Published
    2003

  • Impact Factor
    6.482

Journal of Medicinal Chemistry

Identification of small molecule inhibitors of amyloid β-induced neuronal apoptosis acting through the imidazoline I(2) receptor

Montolio M, Gregori-Puigjané E, Pineda D, Mestres J, Navarro P

  • Published
    2012

  • Impact Factor
    5.248

"It is in     LITERATURE that the concrete outlook of    HUMANITY receives its expression."  Alfred North Whitehead

Reviews

Exploring the Role of Galectins in Cancer: In Vitro and In Vivo Approaches
Methods Mol Bio
2022
PubMed
Impact of Galectins in Resistance to Anticancer Therapies
Clin Can Res
2020
PubMed
The Galectin Family as Molecular Targets: Hopes for Defeating Pancreatic Cancer
Cells
2020
PubMed
Galectins in the Tumor Microenvironment: Focus on Galectin-1.
Adv Exp Med Biol
2020
PubMed
Galectins in prostate and bladder cancer: tumorigenic roles and clinical opportunities
Nat Rev Urol
2019
PubMed
Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy
Cancers (Basel)
2018
PubMed
Poly(ADP-Ribose) Polymerases: New Players in the Pathogenesis of Exocrine Pancreatic Diseases
Am J Pathol
2016
PubMed
Targeting Galectin-1 in pancreatic cancer: immune surveillance on guard
Oncoimmunology
2014
PubMed
Pancreatic ductal adenocarcinoma and transcription factors: role of c-Myc
J Gastrointest Cancer
2011
PubMed
Pancreatic ductal adenocarcinoma: cellular origin, signaling pathways and stroma contribution
Pancreatology
2008
PubMed
Galectin-1 as a therapeutic target in pancreatic cancer: the tumor stroma in the spotlight
Can Cell & Microenv
2014
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Glycans and galectins: sweet new approaches in pancreatic cancer diagnosis and treatment
Pancreatic Cancer
2012
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Collaborations

Sialyltransferase Inhibitor Ac53FaxNeu5Ac Reverts the Malignant Phenotype of Pancreatic Cancer Cells, and Reduces Tumor Volume and Favors T-Cell Infiltrates in Mice
Cancers (Basel)
2022
PubMed
Peptides against Low Density Lipoprotein (LDL) Aggregation Inhibit Intracellular Cholesteryl Ester Loading and Proliferation of Pancreatic Tumor Cells
Cancers (Basel)
2022
PubMed
Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice.
Blood
2022
PubMed
CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease
Sci Transl Med
2021
PubMed
Electrochemical Immunosensing of ST2: A Checkpoint Target in Cancer Diseases
Biosensors (Basel)
2021
PubMed
Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice.
Blood
2021
PubMed
Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion
Int J Mol Sci
2020
PubMed
Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing
Nature
2018
PubMed
Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies
Nat Commun
2017
PubMed
A novel translational control mechanism involving RNA structures within coding sequences
Genome Res
2017
PubMed
Snail1 is required for the maintenance of the pancreatic acinar phenotype
Oncotarget
2016
PubMed
Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease
Gastroenterology
2016
PubMed
The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1
Mol Cell Biol
2014
PubMed
Intraductal delivery of adenoviruses targets pancreatic tumors in transgenic Ela-myc mice and orthotopic xenografts
Oncotarget
2013
PubMed
FDG PET imaging of Ela1-myc mice reveals major biological differences between pancreatic acinar and ductal tumours
Eur J Nucl Med Mol Imaging
2009
PubMed
S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility
Br J Can
2009
PubMed
Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains
EMBO Rep.
2003
PubMed