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PNavarro LAB

Publications

Publications
Proceedings of the National Academy of Sciences

Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor-stroma crosstalk

Orozco CA, Martinez-Bosch N, Guerrero PE, Vinaixa J, Dalotto-Moreno T, Iglesias M, Moreno M, Djurec M, Poirier F, Gabius HJ, Fernandez-Zapico ME, Hwang RF, Guerra C, Rabinovich GA, Navarro P

  • Published
    2018

  • Impact Factor
    9.553

Oncotarget

Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker

Martinez-Bosch N, Barranco LE, Orozco CA, Moreno M, Visa L, Iglesias M, Oldfield L, Neoptolemos JP, Greenhalf W, Earl J, Carrato A, Costello E, Navarro P

  • Published
    2018

Cancer Research

Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation

Martínez-Bosch N, Fernández-Barrena MG, Moreno M, Ortiz-Zapater E, Munné-Collado J, Iglesias M, André S, Gabius HJ, Hwang RF, Poirier F, Navas C, Guerra C, Fernández-Zapico ME, Navarro P

  • Published
    2014

  • Impact Factor
    9.280

Journal of Pathology

Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer

Martínez-Bosch N, Iglesias M, Munné-Collado J, Martínez-Cáceres C, Moreno M, Guerra C, Yélamos J, Navarro P

  • Published
    2014

  • Impact Factor
    7.585

Glia

Tpa induces microglial inflammation via a noncatalytic molecular mechanism involving activation of MAPK and Akt signaling pathways and AnxA2 and Gal-1 receptors.

Pineda D, Ampurdanés C, Medina MG, Serratosa J, Tusell JM, Saura J, Planas AM, Navarro P

  • Published
    2012

  • Impact Factor
    5.186

Oncotarget

The pancreatic niche inhibits the effectiveness of sunitinib treatment of pancreatic cancer

Martínez-Bosch N, Guerrero PE, Moreno M, José A, Iglesias M, Munné-Collado J, Anta H, Gibert J, Orozco CA, Vinaixa J, Fillat C, Viñals F, Navarro P

  • Published
    2016

  • Impact Factor
    6.359

Nature Medicine

Key contribution of CPEB4-mediated translational control to cancer progression

Ortiz-Zapater E, Pineda P, Martínez-Bosch N, Fernández-Miranda G, Iglesias M, Alameda F, Moreno M, Eliscovich C, Eyras E, Real FX, Méndez R, Navarro P

  • Published
    2011

  • Impact Factor
    22.864

Gastroenterology

Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer

Roda O, Ortiz-Zapater E, Martínez-Bosch N, Gutiérrez-Gallego R, Vila-Perelló M, Ampurdanés C, Gabius HJ, André S, Andreu D, Real FX, Navarro P

  • Published
    2009

  • Impact Factor
    12.899

The American Journal of Pathology

Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2

Ortiz-Zapater E, Peiró S, Roda O, Corominas JM, Aguilar S, Ampurdanés C, Real FX, Navarro P

  • Published
    2007

  • Impact Factor
    5.487

Proteomics

A proteomic approach to the identification of new tPA receptors in pancreatic cancer cells

Roda O, Chiva C, Espuña G, Gabius HJ, Real FX, Navarro P, Andreu D

  • Published
    2006

  • Impact Factor
    5.735

The EMBO journal

Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation

Medina MG, Ledesma MD, Domínguez JE, Medina M, Zafra D, Alameda F, Dotti CG, Navarro P

  • Published
    2005

  • Impact Factor
    10.053

The American Journal of Pathology

Tissue plasminogen activator in murine exocrine pancreas cancer: selective expression in ductal tumors and contribution to cancer progression

Aguilar S, Corominas JM, Malats N, Pereira JA, Dufresne M, Real FX, Navarro P

  • Published
    2004

  • Impact Factor
    6.441

The Journal of Biological Chemistry

New insights into the tPA-annexin A2 interaction. Is annexin A2 CYS8 the sole requirement for this association?

Roda O, Valero ML, Peiró S, Andreu D, Real FX, Navarro P

  • Published
    2003

  • Impact Factor
    6.482

Journal of Medicinal Chemistry

Identification of small molecule inhibitors of amyloid β-induced neuronal apoptosis acting through the imidazoline I(2) receptor

Montolio M, Gregori-Puigjané E, Pineda D, Mestres J, Navarro P

  • Published
    2012

  • Impact Factor
    5.248

"It is in     LITERATURE that the concrete outlook of    HUMANITY receives its expression."  Alfred North Whitehead

Collaborations